Shutter Stock
There are many bacteria that live in our mouths, one of which is Streptococcus Gordonii. A recent study found that, the bacterium Streptococcus Gordonii y ang get into the blood stream can cause blood clots and lead to endocarditis (inflammation of the lining of the heart).
Thus the results presented research scientists from the Royal College of Surgeons in the Society for General Microbiology's Spring Conference, Dublin Ireland this week.
Streptococcus Gordonii is a type of bacteria in the mouth and has contributed in the formation of plaque on tooth surfaces. If the bacteria enter the bloodstream through the gums are bleeding, they will wreak havoc by posing as a human protein.
Researchers from the Royal College of Surgeons, Ireland (RCSI) and University of Bristol have found that S. Gordonii is able to produce molecules that mimic human proteins fibrinogen, and cause clots in the blood vessels. Platelet clumping can cause endocarditis, or inflammation of blood vessels that can block the blood supply to the heart and brain.
Dr Helen Petersen, said, with a better understanding of the relationship between bacteria and the risk of blood clots, it can help especially in the treatment of infective endocarditis do. Infective endocarditis is an infection of the heart valves, which are usually caused by bacteria.
"About 30 percent of people with infective endocarditis will die and most require heart valve replacement surgery who have been infected, with valves made of metal or animals," says Dr. Petersen.
"Our team has now identified the components of S. Gordonii molecules that mimic fibrinogen, so we are getting closer to be able to design new compounds to block it. This will prevent the stimulation of unwanted blood clots," continued Dr Steve Kerrigan from the RCSI.
In addition, researchers were also more extensively studied other bacteria in dental plaque that may have an effect similar to S. Gordonii. "We also try to study the properties of other bacteria that have a relationship with S. Gordonii. Our findings clearly show how important it is to maintain oral hygiene and dental hygiene by brushing teeth regularly," said Dr. Petersen
Thus the results presented research scientists from the Royal College of Surgeons in the Society for General Microbiology's Spring Conference, Dublin Ireland this week.
Streptococcus Gordonii is a type of bacteria in the mouth and has contributed in the formation of plaque on tooth surfaces. If the bacteria enter the bloodstream through the gums are bleeding, they will wreak havoc by posing as a human protein.
Researchers from the Royal College of Surgeons, Ireland (RCSI) and University of Bristol have found that S. Gordonii is able to produce molecules that mimic human proteins fibrinogen, and cause clots in the blood vessels. Platelet clumping can cause endocarditis, or inflammation of blood vessels that can block the blood supply to the heart and brain.
Dr Helen Petersen, said, with a better understanding of the relationship between bacteria and the risk of blood clots, it can help especially in the treatment of infective endocarditis do. Infective endocarditis is an infection of the heart valves, which are usually caused by bacteria.
"About 30 percent of people with infective endocarditis will die and most require heart valve replacement surgery who have been infected, with valves made of metal or animals," says Dr. Petersen.
"Our team has now identified the components of S. Gordonii molecules that mimic fibrinogen, so we are getting closer to be able to design new compounds to block it. This will prevent the stimulation of unwanted blood clots," continued Dr Steve Kerrigan from the RCSI.
In addition, researchers were also more extensively studied other bacteria in dental plaque that may have an effect similar to S. Gordonii. "We also try to study the properties of other bacteria that have a relationship with S. Gordonii. Our findings clearly show how important it is to maintain oral hygiene and dental hygiene by brushing teeth regularly," said Dr. Petersen
.KOMPAS.com - Ada banyak bakteri yang hidup di mulut kita, salah satunya adalah Streptococcus gordonii. Sebuah riset terbaru menemukan bahwa, bakteri Streptococcus gordonii yang masuk ke dalam aliran darah dapat menyebabkan pembekuan darah dan memicu endokarditis (peradangan pada lapisan dalam jantung).
Demikian hasil riset yang dipresentasikan para ilmuwan dari Royal College of Surgeons dalam Society for General Microbiology Spring Conference, Dublin Irlandia pekan ini.
Streptococcus gordonii merupakan jenis bakteri yang ada di dalam mulut dan memiliki kontribusi dalam pembentukan plak pada permukaan gigi. Jika bakteri itu masuk ke dalam aliran darah melalui gusi yang berdarah, mereka akan mendatangkan malapetaka dengan menyamar sebagai protein manusia.
Peneliti dari Royal College of Surgeons, Irlandia (RCSI) dan University of Bristol telah menemukan bahwa S. gordonii mampu menghasilkan molekul yang meniru fibrinogen protein manusia, dan menyebabkan penggumpalan di dalam pembuluh darah. Penggumpalan trombosit dapat menyebabkan endokarditis atau peradangan pembuluh darah yang dapat menghentikan suplai darah ke jantung dan otak.
Dr Helen Petersen, mengatakan, dengan adanya pemahaman yang lebih baik tentang hubungan antara bakteri dan risiko pembekuan darah, hal ini bisa membantu khususnya dalam melakukan pengobatan endokarditis infektif. Endokarditis infektif adalah infeksi pada katup-katup jantung, yang biasanya disebabkan oleh bakteri.
"Sekitar 30 persen orang dengan endokarditis infektif akan mati dan sebagian besar memerlukan operasi penggantian katup jantung yang telah terinfeksi, dengan katup yang terbuat dari logam atau hewan," kata Dr Petersen.
"Tim kami kini telah mengidentifikasi komponen-komponen dari molekul S. gordonii yang meniru fibrinogen, sehingga kita semakin dekat untuk dapat merancang senyawa baru untuk menghambatnya. Hal ini akan mencegah stimulasi pembekuan darah yang tidak diinginkan," sambung Dr Steve Kerrigan dari RCSI.
Selain itu, peneliti secara lebih luas juga turut mengamati bakteri lain pada plak gigi yang mungkin memiliki efek mirip dengan S. Gordonii. "Kami juga mencoba mempelajari sifat bakteri lain yang memiliki hubungan dengan S. gordonii. Temuan kami jelas menunjukkan betapa pentingnya untuk menjaga mulut kebersihan dan kesehatan gigi dengan menyikat gigi secara teratur," tegas Dr Petersen
No comments:
Post a Comment